Since this latest patch, I have twice run into a problem where my keyboard or mouse, but not both at the same time, do not work.
The first time that it happened I was in a game, and about halfway through the game, I returned to base. After purchasing items, I clicked a spot on the map to move to. The cursor was fully functional, but it didn't give me the visual confirmation of clicking on the spot. And my Champ didn't move. I had to log-relog and then I got stuck on 80% loading and was not let back into the game until it was over.
The second time it happened was about thirty minutes ago today. I was waiting to start a game, and I was trying to apply my points to ny Champ. I do this by using the CTRL + key method. I was unable to select the skills like this, so I used the mouse to do so. After getting my skills, I tried to use the skills by pressing the appropriate key. Nothing happened. I was able to use the mouse to move, and to activate the skills, but the keyboard itself was rendered useless. I was fortunate in that I relogged and was able to again use the keyboard. Unfortunately, it felt as though there was a severe delay between press and skill activation.